Braak stage 1, 100% of pigmented neurons left
parkinsonconnecting

Gene record

CABLES1

Cdk5 and Abl enzyme substrate 1

translation score 0.45, read 2026-10-29; 2 sealed predictions, 0 held; 3 receipts.

Six readers

readerfoundscore
genetics
Open Targets		no genetic evidence; overall 0.00 from other evidence0.00
cell type
Human Protein Atlas		cell type enhanced, including astrocytes; strongest in endometrial glandular cells0.75
chemistry
Open Targets		hard to drug0.00
trials
ClinicalTrials.gov		2 Parkinson's trials, 0 stopped1.00
literature
PubMed		no papers tie it to Parkinson's yet1.00
pathways
Reactome		3 pathways; mostly other0.30

No case: the score is under the bar. Receipt 14164

Sealed predictions

  1. CABLES1 in dopamine neurons, braak-0.33 (p 0.386) → -0.76 (p 0.017)receipt 14172
  2. CABLES1 in astrocytes, braak-0.07 (p 0.849) → +0.00 (p 1.000)receipt 14171

Swarm cases

receipt 14172: CABLES1 in dopamine neurons, braak

power
full sample -0.50 (p 0.036, n 18), 95% CI -0.78 to -0.04. the interval excludes zero: something may be there, smaller than a half can see.
confounder
adjusted for sex: -0.52 (p 0.027, n 18). holds up.
composition
dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: -0.63 (p 0.0053, n 18). not the mix.
skeptic
leave-one-out range -0.66 to -0.43, sign flips 0; without severely affected donors -0.50 (p 0.036, n 18). robust.
cell type
no other cell group does better.
axis
no measure beats "tracks Braak Lewy-body stage" for CABLES1 in dopamine neurons.

case closed: nothing better to follow up.

receipt 14171: CABLES1 in astrocytes, braak

power
full sample -0.18 (p 0.482, n 18), 95% CI -0.59 to +0.32. the interval is wide: not enough donors to tell.
confounder
adjusted for sex: -0.22 (p 0.384, n 18). does not hold up.
composition
astrocytes share of nuclei vs axis -0.21 (p 0.413); controlling for it: -0.07 (p 0.787, n 18). could be the mix.
skeptic
leave-one-out range -0.35 to -0.12, sign flips 0; without severely affected donors -0.18 (p 0.482, n 18). fragile.
cell type
no other cell group does better.
axis
no measure beats "tracks Braak Lewy-body stage" for CABLES1 in astrocytes.

case closed: nothing better to follow up.

Receipts

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