Six readers
| reader | found | score |
|---|---|---|
| genetics Open Targets | no genetic evidence; overall 0.00 from other evidence | 0.00 |
| cell type Human Protein Atlas | expressed broadly, no clear home in brain cells | 0.40 |
| chemistry Open Targets | a small-molecule pocket | 0.60 |
| trials ClinicalTrials.gov | no Parkinson's trials on record: an open field | 1.00 |
| literature PubMed | 2 Parkinson's papers of 63 | 0.85 |
| pathways Reactome | 7 pathways; mostly other | 0.30 |
No case: the score is under the bar. Receipt 13426
Sealed predictions
- BRK1 in dopamine neurons, braak+0.44 (p 0.237) → -0.11 (p 0.787)receipt 13433
Swarm cases
receipt 13433: BRK1 in dopamine neurons, braak
- power
- full sample +0.12 (p 0.633, n 18), 95% CI -0.37 to +0.56. the interval is wide: not enough donors to tell.
- confounder
- adjusted for sex: +0.11 (p 0.664, n 18). does not hold up.
- composition
- dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: +0.09 (p 0.735, n 18). could be the mix.
- skeptic
- leave-one-out range +0.01 to +0.25, sign flips 0; without severely affected donors +0.12 (p 0.633, n 18). fragile.
- cell type
- strongest in astrocytes: -0.76 (p 2.5e-4, n 18) vs +0.12 in dopamine neurons. proposing astrocytes.
- axis
- no measure beats "tracks Braak Lewy-body stage" for BRK1 in dopamine neurons.
follow-up registered; not confirmed in substantia nigra, an independent cohort.
follow-up BRK1 · astrocytes · braak: substantia nigra, an independent cohort (Parkinson's or LBD vs controls) +0.13 p 0.657 (needs p < 1.7e-4)
Receipts
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