Six readers
| reader | found | score |
|---|---|---|
| genetics Open Targets | no genetic evidence; overall 0.13 from other evidence | 0.00 |
| cell type Human Protein Atlas | cell type enhanced, including brain excitatory neurons; strongest in cardiomyocytes | 0.75 |
| chemistry Open Targets | reachable by antibody | 0.45 |
| trials ClinicalTrials.gov | 51 Parkinson's trials, 3 stopped | 0.95 |
| literature PubMed | 1,293 Parkinson's papers of 33,637: well-trodden | 0.06 |
| pathways Reactome | 14 pathways; mostly growth signalling | 0.60 |
No case: the score is under the bar. Receipt 2246
Sealed predictions
- BDNF in dopamine neurons, braak+0.08 (p 0.838) → +0.65 (p 0.059)receipt 2254
Swarm cases
receipt 2254: BDNF in dopamine neurons, braak
- power
- full sample +0.31 (p 0.204, n 18), 95% CI -0.18 to +0.68. the interval is wide: not enough donors to tell.
- confounder
- adjusted for sex: +0.31 (p 0.204, n 18). does not hold up.
- composition
- dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: +0.19 (p 0.450, n 18). could be the mix.
- skeptic
- leave-one-out range +0.26 to +0.51, sign flips 0; without severely affected donors +0.31 (p 0.204, n 18). fragile.
- cell type
- no other cell group does better.
- axis
- no measure beats "tracks Braak Lewy-body stage" for BDNF in dopamine neurons.
case closed: nothing better to follow up.
Receipts
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