Six readers
| reader | found | score |
|---|---|---|
| genetics Open Targets | no genetic evidence; overall 0.08 from other evidence | 0.00 |
| cell type Human Protein Atlas | cell type enhanced, including oligodendrocytes; strongest in müller glia | 0.75 |
| chemistry Open Targets | a small-molecule pocket | 0.60 |
| trials ClinicalTrials.gov | no Parkinson's trials on record: an open field | 1.00 |
| literature PubMed | no papers tie it to Parkinson's yet | 1.00 |
| pathways Reactome | 1 pathway; mostly other | 0.30 |
No case: the score is under the bar. Receipt 3295
Sealed predictions
- B3GAT1 in dopamine neurons, braak+0.09 (p 0.815) → -0.34 (p 0.374)receipt 3303
- B3GAT1 in oligodendrocytes, braak-0.10 (p 0.790) → -0.12 (p 0.767)receipt 3302
Swarm cases
receipt 3303: B3GAT1 in dopamine neurons, braak
- power
- full sample -0.10 (p 0.683, n 18), 95% CI -0.54 to +0.38. the interval is wide: not enough donors to tell.
- confounder
- adjusted for sex: -0.10 (p 0.683, n 18). does not hold up.
- composition
- dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: -0.10 (p 0.690, n 18). could be the mix.
- skeptic
- leave-one-out range -0.23 to -0.01, sign flips 0; without severely affected donors -0.10 (p 0.683, n 18). fragile.
- cell type
- no other cell group does better.
- axis
- no measure beats "tracks Braak Lewy-body stage" for B3GAT1 in dopamine neurons.
case closed: nothing better to follow up.
receipt 3302: B3GAT1 in oligodendrocytes, braak
- power
- full sample -0.15 (p 0.544, n 18), 95% CI -0.58 to +0.34. the interval is wide: not enough donors to tell.
- confounder
- adjusted for sex: -0.18 (p 0.482, n 18). does not hold up.
- composition
- oligodendrocytes share of nuclei vs axis +0.03 (p 0.915); controlling for it: -0.22 (p 0.374, n 18). could be the mix.
- skeptic
- leave-one-out range -0.33 to -0.05, sign flips 0; without severely affected donors -0.15 (p 0.544, n 18). fragile.
- cell type
- no other cell group does better.
- axis
- no measure beats "tracks Braak Lewy-body stage" for B3GAT1 in oligodendrocytes.
case closed: nothing better to follow up.
Receipts
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