Six readers
| reader | found | score |
|---|---|---|
| genetics Open Targets | genetic association 0.38 (overall 0.25) | 0.38 |
| cell type Human Protein Atlas | expressed broadly, no clear home in brain cells | 0.40 |
| chemistry Open Targets | a small-molecule pocket | 0.50 |
| trials ClinicalTrials.gov | no Parkinson's trials on record: an open field | 1.00 |
| literature PubMed | 46 Parkinson's papers of 482 | 0.49 |
| pathways Reactome | 2 pathways; mostly iron and oxidative stress | 0.80 |
No case: the score is under the bar. Receipt 1689
Sealed predictions
- ATXN3 in dopamine neurons, braak-0.75 (p 0.021) → -0.05 (p 0.893)receipt 1695
Swarm cases
receipt 1695: ATXN3 in dopamine neurons, braak
- power
- full sample -0.29 (p 0.243, n 18), 95% CI -0.67 to +0.20. the interval is wide: not enough donors to tell.
- confounder
- adjusted for sex: -0.29 (p 0.243, n 18). does not hold up.
- composition
- dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: -0.18 (p 0.482, n 18). could be the mix.
- skeptic
- leave-one-out range -0.46 to -0.20, sign flips 0; without severely affected donors -0.29 (p 0.243, n 18). fragile.
- cell type
- no other cell group does better.
- axis
- no measure beats "tracks Braak Lewy-body stage" for ATXN3 in dopamine neurons.
case closed: nothing better to follow up.
Receipts
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