Six readers
| reader | found | score |
|---|---|---|
| genetics Open Targets | no genetic evidence; overall 0.00 from other evidence | 0.00 |
| cell type Human Protein Atlas | cell type enhanced, including oligodendrocyte progenitor cells; strongest in pituicytes/fscs | 0.75 |
| chemistry Open Targets | reachable by antibody | 0.36 |
| trials ClinicalTrials.gov | no Parkinson's trials on record: an open field | 1.00 |
| literature PubMed | no papers tie it to Parkinson's yet | 1.00 |
| pathways Reactome | in no curated pathway | 0.00 |
No case: the score is under the bar. Receipt 14314
Sealed predictions
- ASTN2 in dopamine neurons, braak-0.45 (p 0.224) → -0.16 (p 0.680)receipt 14323
- ASTN2 in oligodendrocytes, braak-0.19 (p 0.623) → -0.11 (p 0.784)receipt 14322
Swarm cases
receipt 14323: ASTN2 in dopamine neurons, braak
- power
- full sample -0.33 (p 0.179, n 18), 95% CI -0.69 to +0.16. the interval is wide: not enough donors to tell.
- confounder
- adjusted for sex: -0.39 (p 0.109, n 18). does not hold up.
- composition
- dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: -0.43 (p 0.075, n 18). could be the mix.
- skeptic
- leave-one-out range -0.49 to -0.25, sign flips 0; without severely affected donors -0.33 (p 0.179, n 18). fragile.
- cell type
- no other cell group does better.
- axis
- no measure beats "tracks Braak Lewy-body stage" for ASTN2 in dopamine neurons.
case closed: nothing better to follow up.
receipt 14322: ASTN2 in oligodendrocytes, braak
- power
- full sample -0.10 (p 0.702, n 18), 95% CI -0.54 to +0.39. the interval is wide: not enough donors to tell.
- confounder
- adjusted for sex: -0.01 (p 0.962, n 18). does not hold up.
- composition
- oligodendrocytes share of nuclei vs axis +0.03 (p 0.915); controlling for it: -0.08 (p 0.767, n 18). could be the mix.
- skeptic
- leave-one-out range -0.23 to +0.03, sign flips 2; without severely affected donors -0.10 (p 0.702, n 18). fragile.
- cell type
- no other cell group does better.
- axis
- no measure beats "tracks Braak Lewy-body stage" for ASTN2 in oligodendrocytes.
case closed: nothing better to follow up.
Receipts
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