Six readers
| reader | found | score |
|---|---|---|
| genetics Open Targets | no genetic evidence; overall 0.00 from other evidence | 0.00 |
| cell type Human Protein Atlas | cell type enhanced, including oligodendrocyte progenitor cells; strongest in endometrial stromal cells | 0.75 |
| chemistry Open Targets | reachable by antibody | 0.45 |
| trials ClinicalTrials.gov | no Parkinson's trials on record: an open field | 1.00 |
| literature PubMed | 1 Parkinson's papers of 77 | 0.91 |
| pathways Reactome | in no curated pathway | 0.00 |
No case: the score is under the bar. Receipt 12908
Sealed predictions
- APCDD1 in dopamine neurons, braak-0.45 (p 0.219) → -0.75 (p 0.019)receipt 12916
- APCDD1 in oligodendrocytes, braak-0.55 (p 0.123) → -0.07 (p 0.859)receipt 12915
Swarm cases
receipt 12916: APCDD1 in dopamine neurons, braak
- power
- full sample -0.60 (p 0.0089, n 18), 95% CI -0.83 to -0.18. the interval excludes zero: something may be there, smaller than a half can see.
- confounder
- adjusted for sex: -0.62 (p 0.0064, n 18). holds up.
- composition
- dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: -0.62 (p 0.0064, n 18). not the mix.
- skeptic
- leave-one-out range -0.72 to -0.53, sign flips 0; without severely affected donors -0.60 (p 0.0089, n 18). robust.
- cell type
- no other cell group does better.
- axis
- no measure beats "tracks Braak Lewy-body stage" for APCDD1 in dopamine neurons.
case closed: nothing better to follow up.
receipt 12915: APCDD1 in oligodendrocytes, braak
- power
- full sample -0.26 (p 0.306, n 18), 95% CI -0.65 to +0.24. the interval is wide: not enough donors to tell.
- confounder
- adjusted for sex: -0.23 (p 0.360, n 18). does not hold up.
- composition
- oligodendrocytes share of nuclei vs axis +0.03 (p 0.915); controlling for it: -0.31 (p 0.204, n 18). could be the mix.
- skeptic
- leave-one-out range -0.44 to -0.15, sign flips 0; without severely affected donors -0.26 (p 0.306, n 18). fragile.
- cell type
- strongest in dopamine neurons: -0.60 (p 0.0089, n 18) vs -0.26 in oligodendrocytes. proposing dopamine neurons.
- axis
- no measure beats "tracks Braak Lewy-body stage" for APCDD1 in oligodendrocytes.
follow-up registered; not confirmed in substantia nigra, an independent cohort.
follow-up APCDD1 · dopamine neurons · braak: substantia nigra, an independent cohort (Parkinson's or LBD vs controls) -0.38 p 0.182 (needs p < 1.7e-4)
Receipts
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