Six readers
| reader | found | score |
|---|---|---|
| genetics Open Targets | genetic association 0.22 (overall 0.14) | 0.22 |
| cell type Human Protein Atlas | expressed broadly, no clear home in brain cells | 0.40 |
| chemistry Open Targets | a small-molecule pocket | 0.60 |
| trials ClinicalTrials.gov | no Parkinson's trials on record: an open field | 1.00 |
| literature PubMed | 1 Parkinson's papers of 184 | 0.91 |
| pathways Reactome | 1 pathway; mostly other | 0.30 |
No case: the score is under the bar. Receipt 2236
Sealed predictions
- ANTXR2 in dopamine neurons, braak+0.39 (p 0.306) → +0.30 (p 0.428)receipt 2242
Swarm cases
receipt 2242: ANTXR2 in dopamine neurons, braak
- power
- full sample +0.49 (p 0.039, n 18), 95% CI +0.03 to +0.78. the interval excludes zero: something may be there, smaller than a half can see.
- confounder
- adjusted for sex: +0.46 (p 0.057, n 18). does not hold up.
- composition
- dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: +0.47 (p 0.051, n 18). could be the mix.
- skeptic
- leave-one-out range +0.42 to +0.62, sign flips 0; without severely affected donors +0.49 (p 0.039, n 18). robust.
- cell type
- no other cell group does better.
- axis
- no measure beats "tracks Braak Lewy-body stage" for ANTXR2 in dopamine neurons.
case closed: nothing better to follow up.
Receipts
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