Six readers
| reader | found | score |
|---|---|---|
| genetics Open Targets | no genetic evidence; overall 0.05 from other evidence | 0.00 |
| cell type Human Protein Atlas | cell type enhanced in other brain neurons (7 nCPM) | 1.00 |
| chemistry Open Targets | hard to drug | 0.00 |
| trials ClinicalTrials.gov | no Parkinson's trials on record: an open field | 1.00 |
| literature PubMed | no papers tie it to Parkinson's yet | 1.00 |
| pathways Reactome | in no curated pathway | 0.00 |
No case: the score is under the bar. Receipt 4862
Sealed predictions
- AIRE in dopamine neurons, braak-0.28 (p 0.472) → -0.62 (p 0.078)receipt 4869
Swarm cases
receipt 4869: AIRE in dopamine neurons, braak
- power
- full sample -0.43 (p 0.074, n 18), 95% CI -0.75 to +0.04. the interval is wide: not enough donors to tell.
- confounder
- adjusted for sex: -0.43 (p 0.074, n 18). does not hold up.
- composition
- dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: -0.58 (p 0.013, n 18). not the mix.
- skeptic
- leave-one-out range -0.55 to -0.36, sign flips 0; without severely affected donors -0.43 (p 0.074, n 18). robust.
- cell type
- strongest in astrocytes: -0.63 (p 0.0055, n 18) vs -0.43 in dopamine neurons. proposing astrocytes.
- axis
- no measure beats "tracks Braak Lewy-body stage" for AIRE in dopamine neurons.
follow-up registered; not confirmed in substantia nigra, an independent cohort.
follow-up AIRE · astrocytes · braak: substantia nigra, an independent cohort (Parkinson's or LBD vs controls) -0.38 p 0.183 (needs p < 4.0e-4)
Receipts
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