Six readers
| reader | found | score |
|---|---|---|
| genetics Open Targets | no genetic evidence; overall 0.00 from other evidence | 0.00 |
| cell type Human Protein Atlas | expressed broadly, no clear home in brain cells | 0.40 |
| chemistry Open Targets | a small-molecule pocket | 0.60 |
| trials ClinicalTrials.gov | no Parkinson's trials on record: an open field | 1.00 |
| literature PubMed | no papers tie it to Parkinson's yet | 1.00 |
| pathways Reactome | 2 pathways; mostly protein handling | 0.90 |
No case: the score is under the bar. Receipt 14740
Sealed predictions
- ADAM8 in dopamine neurons, braak-0.53 (p 0.143) → +0.11 (p 0.777)receipt 14747
Swarm cases
receipt 14747: ADAM8 in dopamine neurons, braak
- power
- full sample -0.23 (p 0.355, n 18), 95% CI -0.63 to +0.26. the interval is wide: not enough donors to tell.
- confounder
- adjusted for sex: -0.23 (p 0.365, n 18). does not hold up.
- composition
- dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: -0.32 (p 0.198, n 18). could be the mix.
- skeptic
- leave-one-out range -0.41 to -0.13, sign flips 0; without severely affected donors -0.23 (p 0.355, n 18). fragile.
- cell type
- strongest in microglia: -0.61 (p 0.0077, n 18) vs -0.23 in dopamine neurons. proposing microglia.
- axis
- no measure beats "tracks Braak Lewy-body stage" for ADAM8 in dopamine neurons.
follow-up registered; not confirmed in substantia nigra, an independent cohort.
follow-up ADAM8 · microglia · braak: substantia nigra, an independent cohort (Parkinson's or LBD vs controls) +0.27 p 0.328 (needs p < 1.6e-4)
Receipts
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