Six readers
| reader | found | score |
|---|---|---|
| genetics Open Targets | no genetic evidence; overall 0.00 from other evidence | 0.00 |
| cell type Human Protein Atlas | expressed broadly, no clear home in brain cells | 0.40 |
| chemistry Open Targets | a small-molecule pocket | 0.60 |
| trials ClinicalTrials.gov | no Parkinson's trials on record: an open field | 1.00 |
| literature PubMed | 1 Parkinson's papers of 48 | 0.91 |
| pathways Reactome | 2 pathways; mostly mitochondrial quality control | 1.00 |
No case: the score is under the bar. Receipt 14927
Sealed predictions
- ACAD8 in dopamine neurons, braak-0.09 (p 0.820) → +0.18 (p 0.639)receipt 14933
Swarm cases
receipt 14933: ACAD8 in dopamine neurons, braak
- power
- full sample -0.00 (p 0.997, n 18), 95% CI -0.47 to +0.47. the interval is wide: not enough donors to tell.
- confounder
- adjusted for sex: +0.04 (p 0.874, n 18). does not hold up.
- composition
- dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: -0.08 (p 0.748, n 18). could be the mix.
- skeptic
- leave-one-out range -0.08 to +0.14, sign flips 7; without severely affected donors -0.00 (p 0.997, n 18). fragile.
- cell type
- strongest in astrocytes: +0.68 (p 0.0018, n 18) vs -0.00 in dopamine neurons. proposing astrocytes.
- axis
- no measure beats "tracks Braak Lewy-body stage" for ACAD8 in dopamine neurons.
follow-up registered; not confirmed in substantia nigra, an independent cohort.
follow-up ACAD8 · astrocytes · braak: substantia nigra, an independent cohort (Parkinson's or LBD vs controls) +0.18 p 0.534 (needs p < 1.5e-4)
Receipts
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