Braak stage 1, 100% of pigmented neurons left
parkinsonconnecting

Gene record

ABTB3

ankyrin repeat and BTB domain containing 3

translation score 0.46, read 2026-10-31; 1 sealed predictions, 0 held; 2 receipts.

Six readers

readerfoundscore
genetics
Open Targets
no genetic evidence; overall 0.00 from other evidence0.00
cell type
Human Protein Atlas
cell type enhanced, including brain inhibitory neurons; strongest in esophageal suprabasal cells0.75
chemistry
Open Targets
reachable by antibody0.36
trials
ClinicalTrials.gov
no Parkinson's trials on record: an open field1.00
literature
PubMed
no papers tie it to Parkinson's yet1.00
pathways
Reactome
in no curated pathway0.00

No case: the score is under the bar. Receipt 15925

Sealed predictions

  1. ABTB3 in dopamine neurons, braakn/a → n/areceipt 15932

Swarm cases

receipt 15932: ABTB3 in dopamine neurons, braak

cell type
ABTB3 is not measured in dopamine neurons; looking elsewhere.
cell type
no other cell group does better.
axis
no measure beats "tracks Braak Lewy-body stage" for ABTB3 in dopamine neurons.

case closed: nothing better to follow up.

Receipts

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