Braak stage 1, 100% of pigmented neurons left
parkinsonconnecting

Receipt 9935

A sealed prediction that did not hold.

no effect in discovery (spearman rho -0.17, p 0.656). This receipt's hash covers every field on it, plus the hash of receipt 9934, so changing any earlier receipt would break every one after it. Your browser recomputes it below.

The slip

  1. PARKINSON RECEIPTno. 9935
    25 Oct 2026, 17:11 UTC

    RNF40

    dopamine neurons, braak

    predictionRNF40 in dopamine neurons tracks Braak Lewy-body stage

    registered3cbea06daa016179

    discovery-0.17 p=0.656 n=9

    replication-0.28 p=0.472 n=9

    neededp < 0.05 twice, same sign

    no effect in discovery (spearman rho -0.17, p 0.656)

    dataVolpato et al. 2025, ventral substantia nigra (18 donors)

    NO EFFECT

    4ec1cd6948c5b0e331d52d6c…
    follows 267677d3d857…

Covered by the on-chain checkpoint of receipt 10865 (2026-10-26 13:05 UTC). See the checkpoint on Robinhood Chain. Previous receipt Next

The swarm's case

receipt 9935: RNF40 in dopamine neurons, braak

power
full sample -0.14 (p 0.585, n 18), 95% CI -0.57 to +0.35. the interval is wide: not enough donors to tell.
confounder
adjusted for sex: -0.12 (p 0.627, n 18). does not hold up.
composition
dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: -0.34 (p 0.173, n 18). could be the mix.
skeptic
leave-one-out range -0.24 to -0.03, sign flips 0; without severely affected donors -0.14 (p 0.585, n 18). fragile.
cell type
no other cell group does better.
axis
no measure beats "tracks Braak Lewy-body stage" for RNF40 in dopamine neurons.

case closed: nothing better to follow up.