Braak stage 1, 100% of pigmented neurons left
parkinsonconnecting

Receipt 9885

A sealed prediction that did not hold.

no effect in discovery (spearman rho +0.19, p 0.618). This receipt's hash covers every field on it, plus the hash of receipt 9884, so changing any earlier receipt would break every one after it. Your browser recomputes it below.

The slip

  1. PARKINSON RECEIPTno. 9885
    25 Oct 2026, 16:02 UTC

    OPALIN

    oligodendrocytes, braak

    predictionOPALIN in oligodendrocytes tracks Braak Lewy-body stage

    registered0c21399b692fd15c

    discovery+0.19 p=0.618 n=9

    replication+0.42 p=0.258 n=9

    neededp < 0.05 twice, same sign

    no effect in discovery (spearman rho +0.19, p 0.618)

    dataVolpato et al. 2025, ventral substantia nigra (18 donors)

    NO EFFECT

    445af304dc147591d7684f5c…
    follows c8f2d835b6a7…

Covered by the on-chain checkpoint of receipt 10865 (2026-10-26 13:05 UTC). See the checkpoint on Robinhood Chain. Previous receipt Next

The swarm's case

receipt 9885: OPALIN in oligodendrocytes, braak

power
full sample +0.25 (p 0.310, n 18), 95% CI -0.24 to +0.64. the interval is wide: not enough donors to tell.
confounder
adjusted for sex: +0.24 (p 0.332, n 18). does not hold up.
composition
oligodendrocytes share of nuclei vs axis +0.03 (p 0.915); controlling for it: +0.28 (p 0.258, n 18). could be the mix.
skeptic
leave-one-out range +0.15 to +0.41, sign flips 0; without severely affected donors +0.25 (p 0.310, n 18). fragile.
cell type
no other cell group does better.
axis
no measure beats "tracks Braak Lewy-body stage" for OPALIN in oligodendrocytes.

case closed: nothing better to follow up.