Braak stage 1, 100% of pigmented neurons left
parkinsonconnecting

Receipt 9870

A sealed prediction that did not hold.

no effect in discovery (spearman rho +0.29, p 0.443). This receipt's hash covers every field on it, plus the hash of receipt 9869, so changing any earlier receipt would break every one after it. Your browser recomputes it below.

The slip

  1. PARKINSON RECEIPTno. 9870
    25 Oct 2026, 15:43 UTC

    HRH4

    dopamine neurons, braak

    predictionHRH4 in dopamine neurons tracks Braak Lewy-body stage

    registeredd4056c5a4f6dd228

    discovery+0.29 p=0.443 n=9

    replication-0.52 p=0.151 n=9

    neededp < 0.05 twice, same sign

    no effect in discovery (spearman rho +0.29, p 0.443)

    dataVolpato et al. 2025, ventral substantia nigra (18 donors)

    NO EFFECT

    8dd7d233f6cc0de9ded12c16…
    follows 6173f94ca788…

Covered by the on-chain checkpoint of receipt 10865 (2026-10-26 13:05 UTC). See the checkpoint on Robinhood Chain. Previous receipt Next

The swarm's case

receipt 9870: HRH4 in dopamine neurons, braak

power
full sample -0.06 (p 0.827, n 18), 95% CI -0.51 to +0.42. the interval is wide: not enough donors to tell.
confounder
adjusted for sex: -0.19 (p 0.455, n 18). does not hold up.
composition
dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: -0.25 (p 0.310, n 18). could be the mix.
skeptic
leave-one-out range -0.16 to +0.06, sign flips 2; without severely affected donors -0.06 (p 0.827, n 18). fragile.
cell type
no other cell group does better.
axis
no measure beats "tracks Braak Lewy-body stage" for HRH4 in dopamine neurons.

case closed: nothing better to follow up.