Braak stage 1, 100% of pigmented neurons left
parkinsonconnecting

Receipt 9568

A sealed prediction that did not hold.

no effect in discovery (spearman rho +0.50, p 0.168). This receipt's hash covers every field on it, plus the hash of receipt 9567, so changing any earlier receipt would break every one after it. Your browser recomputes it below.

The slip

  1. PARKINSON RECEIPTno. 9568
    25 Oct 2026, 08:59 UTC

    SF3A1

    dopamine neurons, braak

    predictionSF3A1 in dopamine neurons tracks Braak Lewy-body stage

    registered5e986e511939a549

    discovery+0.50 p=0.168 n=9

    replication-0.49 p=0.181 n=9

    neededp < 0.05 twice, same sign

    no effect in discovery (spearman rho +0.50, p 0.168)

    dataVolpato et al. 2025, ventral substantia nigra (18 donors)

    NO EFFECT

    b5f252618679d8cd59a9097d…
    follows 0a1b4b6d9491…

Covered by the on-chain checkpoint of receipt 10865 (2026-10-26 13:05 UTC). See the checkpoint on Robinhood Chain. Previous receipt Next

The swarm's case

receipt 9568: SF3A1 in dopamine neurons, braak

power
full sample +0.00 (p 0.997, n 18), 95% CI -0.47 to +0.47. the interval is wide: not enough donors to tell.
confounder
adjusted for sex: +0.01 (p 0.962, n 18). does not hold up.
composition
dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: -0.02 (p 0.942, n 18). could be the mix.
skeptic
leave-one-out range -0.10 to +0.15, sign flips 9; without severely affected donors +0.00 (p 0.997, n 18). fragile.
cell type
no other cell group does better.
axis
no measure beats "tracks Braak Lewy-body stage" for SF3A1 in dopamine neurons.

case closed: nothing better to follow up.