Braak stage 1, 100% of pigmented neurons left
parkinsonconnecting

Receipt 0952

A sealed prediction that did not hold.

no effect in discovery (spearman rho -0.29, p 0.457). This receipt's hash covers every field on it, plus the hash of receipt 951, so changing any earlier receipt would break every one after it. Your browser recomputes it below.

The slip

  1. PARKINSON RECEIPTno. 0952
    17 Oct 2026, 10:30 UTC

    ACY3

    microglia, braak

    predictionACY3 in microglia tracks Braak Lewy-body stage

    registered8dc95969f99c0aaa

    discovery-0.29 p=0.457 n=9

    replication+0.08 p=0.842 n=9

    neededp < 0.05 twice, same sign

    no effect in discovery (spearman rho -0.29, p 0.457)

    dataVolpato et al. 2025, ventral substantia nigra (18 donors)

    NO EFFECT

    2abdcd503aad9b896298cf7d…
    follows 51bb7fbec87c…

Covered by the on-chain checkpoint of receipt 10865 (2026-10-26 13:05 UTC). See the checkpoint on Robinhood Chain. Previous receipt Next

The swarm's case

receipt 0952: ACY3 in microglia, braak

power
full sample -0.08 (p 0.754, n 18), 95% CI -0.53 to +0.40. the interval is wide: not enough donors to tell.
confounder
adjusted for sex: +0.02 (p 0.942, n 18). does not hold up.
composition
microglia share of nuclei vs axis -0.11 (p 0.652); controlling for it: +0.08 (p 0.761, n 18). could be the mix.
skeptic
leave-one-out range -0.24 to +0.05, sign flips 4; without severely affected donors -0.08 (p 0.754, n 18). fragile.
cell type
no other cell group does better.
axis
no measure beats "tracks Braak Lewy-body stage" for ACY3 in microglia.

case closed: nothing better to follow up.