Braak stage 1, 100% of pigmented neurons left
parkinsonconnecting

Receipt 9508

A sealed prediction that did not hold.

no effect in discovery (spearman rho -0.52, p 0.150). This receipt's hash covers every field on it, plus the hash of receipt 9507, so changing any earlier receipt would break every one after it. Your browser recomputes it below.

The slip

  1. PARKINSON RECEIPTno. 9508
    25 Oct 2026, 07:39 UTC

    IL27RA

    dopamine neurons, braak

    predictionIL27RA in dopamine neurons tracks Braak Lewy-body stage

    registeredbc9cd3d10495e6b9

    discovery-0.52 p=0.150 n=9

    replication-0.41 p=0.272 n=9

    neededp < 0.05 twice, same sign

    no effect in discovery (spearman rho -0.52, p 0.150)

    dataVolpato et al. 2025, ventral substantia nigra (18 donors)

    NO EFFECT

    29fe742ec1a1df61c71a4f71…
    follows 2ca34caf8700…

Covered by the on-chain checkpoint of receipt 10865 (2026-10-26 13:05 UTC). See the checkpoint on Robinhood Chain. Previous receipt Next

The swarm's case

receipt 9508: IL27RA in dopamine neurons, braak

power
full sample -0.33 (p 0.179, n 18), 95% CI -0.69 to +0.16. the interval is wide: not enough donors to tell.
confounder
adjusted for sex: -0.30 (p 0.221, n 18). does not hold up.
composition
dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: -0.36 (p 0.142, n 18). could be the mix.
skeptic
leave-one-out range -0.40 to -0.25, sign flips 0; without severely affected donors -0.33 (p 0.179, n 18). fragile.
cell type
no other cell group does better.
axis
no measure beats "tracks Braak Lewy-body stage" for IL27RA in dopamine neurons.

case closed: nothing better to follow up.