Braak stage 1, 100% of pigmented neurons left
parkinsonconnecting

Receipt 9501

A sealed prediction that did not hold.

no effect in discovery (spearman rho -0.03, p 0.929). This receipt's hash covers every field on it, plus the hash of receipt 9500, so changing any earlier receipt would break every one after it. Your browser recomputes it below.

The slip

  1. PARKINSON RECEIPTno. 9501
    25 Oct 2026, 07:28 UTC

    TBX3

    dopamine neurons, braak

    predictionTBX3 in dopamine neurons tracks Braak Lewy-body stage

    registereddd0a0fb30e8ef52c

    discovery-0.03 p=0.929 n=9

    replication+0.30 p=0.441 n=9

    neededp < 0.05 twice, same sign

    no effect in discovery (spearman rho -0.03, p 0.929)

    dataVolpato et al. 2025, ventral substantia nigra (18 donors)

    NO EFFECT

    4e9df6cfedcdd10b2969508a…
    follows 436b200a58e9…

Covered by the on-chain checkpoint of receipt 10865 (2026-10-26 13:05 UTC). See the checkpoint on Robinhood Chain. Previous receipt Next

The swarm's case

receipt 9501: TBX3 in dopamine neurons, braak

power
full sample +0.02 (p 0.942, n 18), 95% CI -0.45 to +0.48. the interval is wide: not enough donors to tell.
confounder
adjusted for sex: +0.08 (p 0.748, n 18). does not hold up.
composition
dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: +0.08 (p 0.741, n 18). could be the mix.
skeptic
leave-one-out range -0.08 to +0.13, sign flips 8; without severely affected donors +0.02 (p 0.942, n 18). fragile.
cell type
no other cell group does better.
axis
no measure beats "tracks Braak Lewy-body stage" for TBX3 in dopamine neurons.

case closed: nothing better to follow up.