Braak stage 1, 100% of pigmented neurons left
parkinsonconnecting

Receipt 9044

A sealed prediction that did not hold.

did not replicate (discovery -0.74 p 0.023; held-out -0.13 p 0.739). This receipt's hash covers every field on it, plus the hash of receipt 9043, so changing any earlier receipt would break every one after it. Your browser recomputes it below.

The slip

  1. PARKINSON RECEIPTno. 9044
    24 Oct 2026, 21:41 UTC

    PPP6R2

    dopamine neurons, braak

    predictionPPP6R2 in dopamine neurons tracks Braak Lewy-body stage

    registered0420ea1078aa039e

    discovery-0.74 p=0.023 n=9

    replication-0.13 p=0.739 n=9

    neededp < 0.05 twice, same sign

    did not replicate (discovery -0.74 p 0.023; held-out -0.13 p 0.739)

    dataVolpato et al. 2025, ventral substantia nigra (18 donors)

    DID NOT REPLICATE

    d53a8391905eafab66fefbef…
    follows b0810a790ad9…

Covered by the on-chain checkpoint of receipt 10865 (2026-10-26 13:05 UTC). See the checkpoint on Robinhood Chain. Previous receipt Next

The swarm's case

receipt 9044: PPP6R2 in dopamine neurons, braak

power
full sample -0.42 (p 0.080, n 18), 95% CI -0.74 to +0.05. the interval is wide: not enough donors to tell.
confounder
adjusted for sex: -0.33 (p 0.176, n 18). does not hold up.
composition
dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: -0.33 (p 0.176, n 18). could be the mix.
skeptic
leave-one-out range -0.54 to -0.34, sign flips 0; without severely affected donors -0.42 (p 0.080, n 18). robust.
cell type
no other cell group does better.
axis
no measure beats "tracks Braak Lewy-body stage" for PPP6R2 in dopamine neurons.

case closed: nothing better to follow up.