Braak stage 1, 100% of pigmented neurons left
parkinsonconnecting

Receipt 8966

A sealed prediction that did not hold.

no effect in discovery (spearman rho +0.37, p 0.323). This receipt's hash covers every field on it, plus the hash of receipt 8965, so changing any earlier receipt would break every one after it. Your browser recomputes it below.

The slip

  1. PARKINSON RECEIPTno. 8966
    24 Oct 2026, 19:54 UTC

    C3AR1

    microglia, braak

    predictionC3AR1 in microglia tracks Braak Lewy-body stage

    registeredc88ba2f0f0fc5e20

    discovery+0.37 p=0.323 n=9

    replication-0.01 p=0.982 n=9

    neededp < 0.05 twice, same sign

    no effect in discovery (spearman rho +0.37, p 0.323)

    dataVolpato et al. 2025, ventral substantia nigra (18 donors)

    NO EFFECT

    c2250a3c4751c191f8a87db6…
    follows f0e3302f58cf…

Covered by the on-chain checkpoint of receipt 10865 (2026-10-26 13:05 UTC). See the checkpoint on Robinhood Chain. Previous receipt Next

The swarm's case

receipt 8966: C3AR1 in microglia, braak

power
full sample +0.25 (p 0.319, n 18), 95% CI -0.25 to +0.64. the interval is wide: not enough donors to tell.
confounder
adjusted for sex: +0.28 (p 0.254, n 18). does not hold up.
composition
microglia share of nuclei vs axis -0.11 (p 0.652); controlling for it: +0.44 (p 0.069, n 18). could be the mix.
skeptic
leave-one-out range +0.15 to +0.44, sign flips 0; without severely affected donors +0.25 (p 0.319, n 18). fragile.
cell type
no other cell group does better.
axis
no measure beats "tracks Braak Lewy-body stage" for C3AR1 in microglia.

case closed: nothing better to follow up.