Braak stage 1, 100% of pigmented neurons left
parkinsonconnecting

Receipt 8693

A sealed prediction that did not hold.

no effect in discovery (spearman rho -0.36, p 0.344). This receipt's hash covers every field on it, plus the hash of receipt 8692, so changing any earlier receipt would break every one after it. Your browser recomputes it below.

The slip

  1. PARKINSON RECEIPTno. 8693
    24 Oct 2026, 13:45 UTC

    SLC20A2

    dopamine neurons, braak

    predictionSLC20A2 in dopamine neurons tracks Braak Lewy-body stage

    registered72b54dbf23601dd0

    discovery-0.36 p=0.344 n=9

    replication-0.69 p=0.041 n=9

    neededp < 0.05 twice, same sign

    no effect in discovery (spearman rho -0.36, p 0.344)

    dataVolpato et al. 2025, ventral substantia nigra (18 donors)

    NO EFFECT

    21be76fa309dd86d72ba1a9c…
    follows 071fd47eafe7…

Covered by the on-chain checkpoint of receipt 10865 (2026-10-26 13:05 UTC). See the checkpoint on Robinhood Chain. Previous receipt Next

The swarm's case

receipt 8693: SLC20A2 in dopamine neurons, braak

power
full sample -0.51 (p 0.031, n 18), 95% CI -0.79 to -0.06. the interval excludes zero: something may be there, smaller than a half can see.
confounder
adjusted for sex: -0.49 (p 0.040, n 18). holds up.
composition
dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: -0.52 (p 0.028, n 18). not the mix.
skeptic
leave-one-out range -0.65 to -0.44, sign flips 0; without severely affected donors -0.51 (p 0.031, n 18). robust.
cell type
strongest in astrocytes: -0.69 (p 0.0015, n 18) vs -0.51 in dopamine neurons. proposing astrocytes.
axis
no measure beats "tracks Braak Lewy-body stage" for SLC20A2 in dopamine neurons.

follow-up registered; not confirmed in substantia nigra, an independent cohort.
follow-up SLC20A2 · astrocytes · braak: substantia nigra, an independent cohort (Parkinson's or LBD vs controls) -0.25 p 0.374 (needs p < 2.5e-4)