Braak stage 1, 100% of pigmented neurons left
parkinsonconnecting

Receipt 8594

A sealed prediction that did not hold.

no effect in discovery (spearman rho -0.09, p 0.812). This receipt's hash covers every field on it, plus the hash of receipt 8593, so changing any earlier receipt would break every one after it. Your browser recomputes it below.

The slip

  1. PARKINSON RECEIPTno. 8594
    24 Oct 2026, 11:25 UTC

    MAP2K5

    dopamine neurons, braak

    predictionMAP2K5 in dopamine neurons tracks Braak Lewy-body stage

    registered5d8b0d862db6f2c5

    discovery-0.09 p=0.812 n=9

    replication+0.47 p=0.197 n=9

    neededp < 0.05 twice, same sign

    no effect in discovery (spearman rho -0.09, p 0.812)

    dataVolpato et al. 2025, ventral substantia nigra (18 donors)

    NO EFFECT

    76bbb6f2e5c6431ca9763044…
    follows 6733c396dcae…

Covered by the on-chain checkpoint of receipt 10865 (2026-10-26 13:05 UTC). See the checkpoint on Robinhood Chain. Previous receipt Next

The swarm's case

receipt 8594: MAP2K5 in dopamine neurons, braak

power
full sample +0.26 (p 0.289, n 18), 95% CI -0.23 to +0.65. the interval is wide: not enough donors to tell.
confounder
adjusted for sex: +0.27 (p 0.277, n 18). does not hold up.
composition
dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: +0.25 (p 0.310, n 18). could be the mix.
skeptic
leave-one-out range +0.16 to +0.38, sign flips 0; without severely affected donors +0.26 (p 0.289, n 18). fragile.
cell type
no other cell group does better.
axis
no measure beats "tracks Braak Lewy-body stage" for MAP2K5 in dopamine neurons.

case closed: nothing better to follow up.