Braak stage 1, 100% of pigmented neurons left
parkinsonconnecting

Receipt 8512

A sealed prediction that did not hold.

no effect in discovery (spearman rho +0.04, p 0.912). This receipt's hash covers every field on it, plus the hash of receipt 8511, so changing any earlier receipt would break every one after it. Your browser recomputes it below.

The slip

  1. PARKINSON RECEIPTno. 8512
    24 Oct 2026, 09:34 UTC

    LRRN1

    oligodendrocytes, braak

    predictionLRRN1 in oligodendrocytes tracks Braak Lewy-body stage

    registered7159073075f9624c

    discovery+0.04 p=0.912 n=9

    replication-0.13 p=0.732 n=9

    neededp < 0.05 twice, same sign

    no effect in discovery (spearman rho +0.04, p 0.912)

    dataVolpato et al. 2025, ventral substantia nigra (18 donors)

    NO EFFECT

    61b0c86764c655098fae5718…
    follows 85de2ea33f0d…

Covered by the on-chain checkpoint of receipt 10865 (2026-10-26 13:05 UTC). See the checkpoint on Robinhood Chain. Previous receipt Next

The swarm's case

receipt 8512: LRRN1 in oligodendrocytes, braak

power
full sample -0.06 (p 0.800, n 18), 95% CI -0.52 to +0.42. the interval is wide: not enough donors to tell.
confounder
adjusted for sex: -0.02 (p 0.928, n 18). does not hold up.
composition
oligodendrocytes share of nuclei vs axis +0.03 (p 0.915); controlling for it: -0.02 (p 0.928, n 18). could be the mix.
skeptic
leave-one-out range -0.23 to +0.06, sign flips 5; without severely affected donors -0.06 (p 0.800, n 18). fragile.
cell type
no other cell group does better.
axis
no measure beats "tracks Braak Lewy-body stage" for LRRN1 in oligodendrocytes.

case closed: nothing better to follow up.