Braak stage 1, 100% of pigmented neurons left
parkinsonconnecting

Receipt 0849

A sealed prediction that did not hold.

no effect in discovery (spearman rho +0.01, p 0.982). This receipt's hash covers every field on it, plus the hash of receipt 848, so changing any earlier receipt would break every one after it. Your browser recomputes it below.

The slip

  1. PARKINSON RECEIPTno. 0849
    17 Oct 2026, 08:06 UTC

    PDE7B

    astrocytes, braak

    predictionPDE7B in astrocytes tracks Braak Lewy-body stage

    registered3b6c7ee43c6c8499

    discovery+0.01 p=0.982 n=9

    replication+0.24 p=0.533 n=9

    neededp < 0.05 twice, same sign

    no effect in discovery (spearman rho +0.01, p 0.982)

    dataVolpato et al. 2025, ventral substantia nigra (18 donors)

    NO EFFECT

    3521c88f8522b1299186949c…
    follows 17978a2e59fd…

Covered by the on-chain checkpoint of receipt 10865 (2026-10-26 13:05 UTC). See the checkpoint on Robinhood Chain. Previous receipt Next

The swarm's case

receipt 0849: PDE7B in astrocytes, braak

power
full sample +0.14 (p 0.585, n 18), 95% CI -0.35 to +0.57. the interval is wide: not enough donors to tell.
confounder
adjusted for sex: +0.04 (p 0.861, n 18). does not hold up.
composition
astrocytes share of nuclei vs axis -0.21 (p 0.413); controlling for it: +0.08 (p 0.754, n 18). could be the mix.
skeptic
leave-one-out range +0.01 to +0.27, sign flips 0; without severely affected donors +0.14 (p 0.585, n 18). fragile.
cell type
no other cell group does better.
axis
no measure beats "tracks Braak Lewy-body stage" for PDE7B in astrocytes.

case closed: nothing better to follow up.