Braak stage 1, 100% of pigmented neurons left
parkinsonconnecting

Receipt 8487

A sealed prediction that did not hold.

no effect in discovery (spearman rho -0.34, p 0.374). This receipt's hash covers every field on it, plus the hash of receipt 8486, so changing any earlier receipt would break every one after it. Your browser recomputes it below.

The slip

  1. PARKINSON RECEIPTno. 8487
    24 Oct 2026, 09:02 UTC

    TSC22D4

    dopamine neurons, braak

    predictionTSC22D4 in dopamine neurons tracks Braak Lewy-body stage

    registeredd7115c19d9dc3eec

    discovery-0.34 p=0.374 n=9

    replication-0.34 p=0.373 n=9

    neededp < 0.05 twice, same sign

    no effect in discovery (spearman rho -0.34, p 0.374)

    dataVolpato et al. 2025, ventral substantia nigra (18 donors)

    NO EFFECT

    df7112f082b3de8e6e9a59d3…
    follows 96bcc18920a5…

Covered by the on-chain checkpoint of receipt 10865 (2026-10-26 13:05 UTC). See the checkpoint on Robinhood Chain. Previous receipt Next

The swarm's case

receipt 8487: TSC22D4 in dopamine neurons, braak

power
full sample -0.35 (p 0.156, n 18), 95% CI -0.70 to +0.14. the interval is wide: not enough donors to tell.
confounder
adjusted for sex: -0.35 (p 0.156, n 18). does not hold up.
composition
dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: -0.35 (p 0.150, n 18). could be the mix.
skeptic
leave-one-out range -0.44 to -0.25, sign flips 0; without severely affected donors -0.35 (p 0.156, n 18). fragile.
cell type
no other cell group does better.
axis
no measure beats "tracks Braak Lewy-body stage" for TSC22D4 in dopamine neurons.

case closed: nothing better to follow up.