Braak stage 1, 100% of pigmented neurons left
parkinsonconnecting

Receipt 0847

A sealed prediction that did not hold.

no effect in discovery (spearman rho -0.36, p 0.344). This receipt's hash covers every field on it, plus the hash of receipt 846, so changing any earlier receipt would break every one after it. Your browser recomputes it below.

The slip

  1. PARKINSON RECEIPTno. 0847
    17 Oct 2026, 08:04 UTC

    DNPEP

    dopamine neurons, braak

    predictionDNPEP in dopamine neurons tracks Braak Lewy-body stage

    registeredbaf519ea8ec4e0a4

    discovery-0.36 p=0.344 n=9

    replication-0.28 p=0.472 n=9

    neededp < 0.05 twice, same sign

    no effect in discovery (spearman rho -0.36, p 0.344)

    dataVolpato et al. 2025, ventral substantia nigra (18 donors)

    NO EFFECT

    416fbc62b32e32a481dc4ff3…
    follows 95f9a0e8f18e…

Covered by the on-chain checkpoint of receipt 10865 (2026-10-26 13:05 UTC). See the checkpoint on Robinhood Chain. Previous receipt Next

The swarm's case

receipt 0847: DNPEP in dopamine neurons, braak

power
full sample -0.30 (p 0.225, n 18), 95% CI -0.67 to +0.19. the interval is wide: not enough donors to tell.
confounder
adjusted for sex: -0.29 (p 0.246, n 18). does not hold up.
composition
dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: -0.29 (p 0.246, n 18). could be the mix.
skeptic
leave-one-out range -0.45 to -0.23, sign flips 0; without severely affected donors -0.30 (p 0.225, n 18). fragile.
cell type
no other cell group does better.
axis
no measure beats "tracks Braak Lewy-body stage" for DNPEP in dopamine neurons.

case closed: nothing better to follow up.