Braak stage 1, 100% of pigmented neurons left
parkinsonconnecting

Receipt 8440

A sealed prediction that did not hold.

no effect in discovery (spearman rho +0.37, p 0.329). This receipt's hash covers every field on it, plus the hash of receipt 8439, so changing any earlier receipt would break every one after it. Your browser recomputes it below.

The slip

  1. PARKINSON RECEIPTno. 8440
    24 Oct 2026, 07:58 UTC

    HIVEP3

    dopamine neurons, braak

    predictionHIVEP3 in dopamine neurons tracks Braak Lewy-body stage

    registered231cc9e80769f46a

    discovery+0.37 p=0.329 n=9

    replication-0.67 p=0.049 n=9

    neededp < 0.05 twice, same sign

    no effect in discovery (spearman rho +0.37, p 0.329)

    dataVolpato et al. 2025, ventral substantia nigra (18 donors)

    NO EFFECT

    700595bb7c73e2255ea82149…
    follows b6ff0a2b290b…

Covered by the on-chain checkpoint of receipt 10865 (2026-10-26 13:05 UTC). See the checkpoint on Robinhood Chain. Previous receipt Next

The swarm's case

receipt 8440: HIVEP3 in dopamine neurons, braak

power
full sample -0.20 (p 0.429, n 18), 95% CI -0.61 to +0.30. the interval is wide: not enough donors to tell.
confounder
adjusted for sex: -0.20 (p 0.429, n 18). does not hold up.
composition
dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: -0.48 (p 0.042, n 18). not the mix.
skeptic
leave-one-out range -0.32 to -0.10, sign flips 0; without severely affected donors -0.20 (p 0.429, n 18). fragile.
cell type
no other cell group does better.
axis
no measure beats "tracks Braak Lewy-body stage" for HIVEP3 in dopamine neurons.

case closed: nothing better to follow up.