Braak stage 1, 100% of pigmented neurons left
parkinsonconnecting

Receipt 8340

A sealed prediction that did not hold.

no effect in discovery (spearman rho +0.25, p 0.514). This receipt's hash covers every field on it, plus the hash of receipt 8339, so changing any earlier receipt would break every one after it. Your browser recomputes it below.

The slip

  1. PARKINSON RECEIPTno. 8340
    24 Oct 2026, 05:46 UTC

    DPYSL2

    oligodendrocytes, braak

    predictionDPYSL2 in oligodendrocytes tracks Braak Lewy-body stage

    registered6a92a0454c26f99a

    discovery+0.25 p=0.514 n=9

    replication-0.38 p=0.309 n=9

    neededp < 0.05 twice, same sign

    no effect in discovery (spearman rho +0.25, p 0.514)

    dataVolpato et al. 2025, ventral substantia nigra (18 donors)

    NO EFFECT

    7f08a23f8ca5cc7aaef5cf51…
    follows acd8a09d8007…

Covered by the on-chain checkpoint of receipt 10865 (2026-10-26 13:05 UTC). See the checkpoint on Robinhood Chain. Previous receipt Next

The swarm's case

receipt 8340: DPYSL2 in oligodendrocytes, braak

power
full sample -0.10 (p 0.690, n 18), 95% CI -0.54 to +0.38. the interval is wide: not enough donors to tell.
confounder
adjusted for sex: -0.02 (p 0.928, n 18). does not hold up.
composition
oligodendrocytes share of nuclei vs axis +0.03 (p 0.915); controlling for it: -0.03 (p 0.915, n 18). could be the mix.
skeptic
leave-one-out range -0.24 to -0.01, sign flips 0; without severely affected donors -0.10 (p 0.690, n 18). fragile.
cell type
no other cell group does better.
axis
no measure beats "tracks Braak Lewy-body stage" for DPYSL2 in oligodendrocytes.

case closed: nothing better to follow up.