Braak stage 1, 100% of pigmented neurons left
parkinsonconnecting

Receipt 7877

A sealed prediction that did not hold.

no effect in discovery (spearman rho +0.61, p 0.078). This receipt's hash covers every field on it, plus the hash of receipt 7876, so changing any earlier receipt would break every one after it. Your browser recomputes it below.

The slip

  1. PARKINSON RECEIPTno. 7877
    23 Oct 2026, 20:05 UTC

    SV2B

    dopamine neurons, braak

    predictionSV2B in dopamine neurons tracks Braak Lewy-body stage

    registeredaa2adc8bf9ac1b1d

    discovery+0.61 p=0.078 n=9

    replication-0.05 p=0.893 n=9

    neededp < 0.05 twice, same sign

    no effect in discovery (spearman rho +0.61, p 0.078)

    dataVolpato et al. 2025, ventral substantia nigra (18 donors)

    NO EFFECT

    c22d9be496762bd8b09f0627…
    follows c08f114cf1c3…

Covered by the on-chain checkpoint of receipt 10865 (2026-10-26 13:05 UTC). See the checkpoint on Robinhood Chain. Previous receipt Next

The swarm's case

receipt 7877: SV2B in dopamine neurons, braak

power
full sample +0.26 (p 0.298, n 18), 95% CI -0.24 to +0.65. the interval is wide: not enough donors to tell.
confounder
adjusted for sex: +0.27 (p 0.281, n 18). does not hold up.
composition
dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: +0.24 (p 0.328, n 18). could be the mix.
skeptic
leave-one-out range +0.17 to +0.40, sign flips 0; without severely affected donors +0.26 (p 0.298, n 18). fragile.
cell type
no other cell group does better.
axis
no measure beats "tracks Braak Lewy-body stage" for SV2B in dopamine neurons.

case closed: nothing better to follow up.