Braak stage 1, 100% of pigmented neurons left
parkinsonconnecting

Receipt 7618

A sealed prediction that did not hold.

no effect in discovery (spearman rho +0.37, p 0.323). This receipt's hash covers every field on it, plus the hash of receipt 7617, so changing any earlier receipt would break every one after it. Your browser recomputes it below.

The slip

  1. PARKINSON RECEIPTno. 7618
    23 Oct 2026, 14:18 UTC

    PON2

    astrocytes, braak

    predictionPON2 in astrocytes tracks Braak Lewy-body stage

    registered37ca1a227d5086c4

    discovery+0.37 p=0.323 n=9

    replication+0.37 p=0.329 n=9

    neededp < 0.05 twice, same sign

    no effect in discovery (spearman rho +0.37, p 0.323)

    dataVolpato et al. 2025, ventral substantia nigra (18 donors)

    NO EFFECT

    709fbbdf595b52217b380271…
    follows dfbcecf08c2a…

Covered by the on-chain checkpoint of receipt 10865 (2026-10-26 13:05 UTC). See the checkpoint on Robinhood Chain. Previous receipt Next

The swarm's case

receipt 7618: PON2 in astrocytes, braak

power
full sample +0.32 (p 0.194, n 18), 95% CI -0.17 to +0.69. the interval is wide: not enough donors to tell.
confounder
adjusted for sex: +0.31 (p 0.218, n 18). does not hold up.
composition
astrocytes share of nuclei vs axis -0.21 (p 0.413); controlling for it: +0.29 (p 0.250, n 18). could be the mix.
skeptic
leave-one-out range +0.23 to +0.44, sign flips 0; without severely affected donors +0.32 (p 0.194, n 18). fragile.
cell type
no other cell group does better.
axis
no measure beats "tracks Braak Lewy-body stage" for PON2 in astrocytes.

case closed: nothing better to follow up.