Braak stage 1, 100% of pigmented neurons left
parkinsonconnecting

Receipt 7614

A sealed prediction that did not hold.

no effect in discovery (spearman rho -0.05, p 0.894). This receipt's hash covers every field on it, plus the hash of receipt 7613, so changing any earlier receipt would break every one after it. Your browser recomputes it below.

The slip

  1. PARKINSON RECEIPTno. 7614
    23 Oct 2026, 14:13 UTC

    ISY1

    dopamine neurons, braak

    predictionISY1 in dopamine neurons tracks Braak Lewy-body stage

    registered012c60d82e8685a3

    discovery-0.05 p=0.894 n=9

    replication-0.38 p=0.309 n=9

    neededp < 0.05 twice, same sign

    no effect in discovery (spearman rho -0.05, p 0.894)

    dataVolpato et al. 2025, ventral substantia nigra (18 donors)

    NO EFFECT

    9b69f2b39234b38a38144276…
    follows cef34996c138…

Covered by the on-chain checkpoint of receipt 10865 (2026-10-26 13:05 UTC). See the checkpoint on Robinhood Chain. Previous receipt Next

The swarm's case

receipt 7614: ISY1 in dopamine neurons, braak

power
full sample -0.27 (p 0.273, n 18), 95% CI -0.66 to +0.22. the interval is wide: not enough donors to tell.
confounder
adjusted for sex: -0.25 (p 0.323, n 18). does not hold up.
composition
dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: -0.24 (p 0.346, n 18). could be the mix.
skeptic
leave-one-out range -0.43 to -0.18, sign flips 0; without severely affected donors -0.27 (p 0.273, n 18). fragile.
cell type
no other cell group does better.
axis
no measure beats "tracks Braak Lewy-body stage" for ISY1 in dopamine neurons.

case closed: nothing better to follow up.