Braak stage 1, 100% of pigmented neurons left
parkinsonconnecting

Receipt 7487

A sealed prediction that did not hold.

no effect in discovery (spearman rho -0.47, p 0.197). This receipt's hash covers every field on it, plus the hash of receipt 7486, so changing any earlier receipt would break every one after it. Your browser recomputes it below.

The slip

  1. PARKINSON RECEIPTno. 7487
    23 Oct 2026, 11:14 UTC

    SIX3

    dopamine neurons, braak

    predictionSIX3 in dopamine neurons tracks Braak Lewy-body stage

    registered1abf51e1754fc0e6

    discovery-0.47 p=0.197 n=9

    replication-0.30 p=0.436 n=9

    neededp < 0.05 twice, same sign

    no effect in discovery (spearman rho -0.47, p 0.197)

    dataVolpato et al. 2025, ventral substantia nigra (18 donors)

    NO EFFECT

    5ba0ab7cc2ffb629a414c0dc…
    follows 36ba36880097…

Covered by the on-chain checkpoint of receipt 10865 (2026-10-26 13:05 UTC). See the checkpoint on Robinhood Chain. Previous receipt Next

The swarm's case

receipt 7487: SIX3 in dopamine neurons, braak

power
full sample -0.32 (p 0.194, n 18), 95% CI -0.69 to +0.17. the interval is wide: not enough donors to tell.
confounder
adjusted for sex: -0.36 (p 0.140, n 18). does not hold up.
composition
dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: -0.50 (p 0.034, n 18). not the mix.
skeptic
leave-one-out range -0.49 to -0.23, sign flips 0; without severely affected donors -0.32 (p 0.194, n 18). fragile.
cell type
no other cell group does better.
axis
no measure beats "tracks Braak Lewy-body stage" for SIX3 in dopamine neurons.

case closed: nothing better to follow up.