Braak stage 1, 100% of pigmented neurons left
parkinsonconnecting

Receipt 7422

A sealed prediction that did not hold.

no effect in discovery (spearman rho -0.41, p 0.269). This receipt's hash covers every field on it, plus the hash of receipt 7421, so changing any earlier receipt would break every one after it. Your browser recomputes it below.

The slip

  1. PARKINSON RECEIPTno. 7422
    23 Oct 2026, 09:48 UTC

    KDM6B

    dopamine neurons, braak

    predictionKDM6B in dopamine neurons tracks Braak Lewy-body stage

    registered899307345cda2c14

    discovery-0.41 p=0.269 n=9

    replication-0.39 p=0.297 n=9

    neededp < 0.05 twice, same sign

    no effect in discovery (spearman rho -0.41, p 0.269)

    dataVolpato et al. 2025, ventral substantia nigra (18 donors)

    NO EFFECT

    7c6276cca3618441321feb6e…
    follows 4cba07701d1e…

Covered by the on-chain checkpoint of receipt 10865 (2026-10-26 13:05 UTC). See the checkpoint on Robinhood Chain. Previous receipt Next

The swarm's case

receipt 7422: KDM6B in dopamine neurons, braak

power
full sample -0.42 (p 0.084, n 18), 95% CI -0.74 to +0.06. the interval is wide: not enough donors to tell.
confounder
adjusted for sex: -0.42 (p 0.084, n 18). does not hold up.
composition
dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: -0.53 (p 0.022, n 18). not the mix.
skeptic
leave-one-out range -0.60 to -0.34, sign flips 0; without severely affected donors -0.42 (p 0.084, n 18). robust.
cell type
no other cell group does better.
axis
no measure beats "tracks Braak Lewy-body stage" for KDM6B in dopamine neurons.

case closed: nothing better to follow up.