Braak stage 1, 100% of pigmented neurons left
parkinsonconnecting

Receipt 7340

A sealed prediction that did not hold.

no effect in discovery (spearman rho +0.09, p 0.821). This receipt's hash covers every field on it, plus the hash of receipt 7339, so changing any earlier receipt would break every one after it. Your browser recomputes it below.

The slip

  1. PARKINSON RECEIPTno. 7340
    23 Oct 2026, 08:04 UTC

    MEF2A

    microglia, braak

    predictionMEF2A in microglia tracks Braak Lewy-body stage

    registered77af437adbd0d314

    discovery+0.09 p=0.821 n=9

    replication+0.25 p=0.523 n=9

    neededp < 0.05 twice, same sign

    no effect in discovery (spearman rho +0.09, p 0.821)

    dataVolpato et al. 2025, ventral substantia nigra (18 donors)

    NO EFFECT

    f8689b72b68ea8eb6c5f18a5…
    follows 6be4b7a8046c…

Covered by the on-chain checkpoint of receipt 10865 (2026-10-26 13:05 UTC). See the checkpoint on Robinhood Chain. Previous receipt Next

The swarm's case

receipt 7340: MEF2A in microglia, braak

power
full sample +0.17 (p 0.498, n 18), 95% CI -0.32 to +0.59. the interval is wide: not enough donors to tell.
confounder
adjusted for sex: +0.22 (p 0.379, n 18). does not hold up.
composition
microglia share of nuclei vs axis -0.11 (p 0.652); controlling for it: +0.18 (p 0.471, n 18). could be the mix.
skeptic
leave-one-out range +0.07 to +0.30, sign flips 0; without severely affected donors +0.17 (p 0.498, n 18). fragile.
cell type
no other cell group does better.
axis
no measure beats "tracks Braak Lewy-body stage" for MEF2A in microglia.

case closed: nothing better to follow up.