Braak stage 1, 100% of pigmented neurons left
parkinsonconnecting

Receipt 0722

A sealed prediction that did not hold.

no effect in discovery (spearman rho +0.26, p 0.502). This receipt's hash covers every field on it, plus the hash of receipt 721, so changing any earlier receipt would break every one after it. Your browser recomputes it below.

The slip

  1. PARKINSON RECEIPTno. 0722
    17 Oct 2026, 05:10 UTC

    TTK

    dopamine neurons, braak

    predictionTTK in dopamine neurons tracks Braak Lewy-body stage

    registered640068d1d8a0e863

    discovery+0.26 p=0.502 n=9

    replication+0.63 p=0.068 n=9

    neededp < 0.05 twice, same sign

    no effect in discovery (spearman rho +0.26, p 0.502)

    dataVolpato et al. 2025, ventral substantia nigra (18 donors)

    NO EFFECT

    8dad5596524d91587d91a4af…
    follows e899d91cf22e…

Covered by the on-chain checkpoint of receipt 10865 (2026-10-26 13:05 UTC). See the checkpoint on Robinhood Chain. Previous receipt Next

The swarm's case

receipt 0722: TTK in dopamine neurons, braak

power
full sample +0.43 (p 0.077, n 18), 95% CI -0.05 to +0.75. the interval is wide: not enough donors to tell.
confounder
adjusted for sex: +0.39 (p 0.107, n 18). does not hold up.
composition
dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: +0.39 (p 0.105, n 18). could be the mix.
skeptic
leave-one-out range +0.35 to +0.59, sign flips 0; without severely affected donors +0.43 (p 0.077, n 18). robust.
cell type
no other cell group does better.
axis
no measure beats "tracks Braak Lewy-body stage" for TTK in dopamine neurons.

case closed: nothing better to follow up.