Braak stage 1, 100% of pigmented neurons left
parkinsonconnecting

Receipt 7009

A sealed prediction that did not hold.

no effect in discovery (spearman rho +0.16, p 0.680). This receipt's hash covers every field on it, plus the hash of receipt 7008, so changing any earlier receipt would break every one after it. Your browser recomputes it below.

The slip

  1. PARKINSON RECEIPTno. 7009
    23 Oct 2026, 01:26 UTC

    IL17F

    dopamine neurons, braak

    predictionIL17F in dopamine neurons tracks Braak Lewy-body stage

    registered8e3b832754960237

    discovery+0.16 p=0.680 n=9

    replication+0.27 p=0.485 n=9

    neededp < 0.05 twice, same sign

    no effect in discovery (spearman rho +0.16, p 0.680)

    dataVolpato et al. 2025, ventral substantia nigra (18 donors)

    NO EFFECT

    56c25d7b283d6dac30d0ab54…
    follows 6ed908858377…

Covered by the on-chain checkpoint of receipt 10865 (2026-10-26 13:05 UTC). See the checkpoint on Robinhood Chain. Previous receipt Next

The swarm's case

receipt 7009: IL17F in dopamine neurons, braak

power
full sample +0.24 (p 0.341, n 18), 95% CI -0.26 to +0.63. the interval is wide: not enough donors to tell.
confounder
adjusted for sex: +0.25 (p 0.319, n 18). does not hold up.
composition
dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: +0.22 (p 0.374, n 18). could be the mix.
skeptic
leave-one-out range +0.14 to +0.34, sign flips 0; without severely affected donors +0.24 (p 0.341, n 18). fragile.
cell type
no other cell group does better.
axis
no measure beats "tracks Braak Lewy-body stage" for IL17F in dopamine neurons.

case closed: nothing better to follow up.