Braak stage 1, 100% of pigmented neurons left
parkinsonconnecting

Receipt 6770

A sealed prediction that did not hold.

no effect in discovery (spearman rho -0.21, p 0.586). This receipt's hash covers every field on it, plus the hash of receipt 6769, so changing any earlier receipt would break every one after it. Your browser recomputes it below.

The slip

  1. PARKINSON RECEIPTno. 6770
    22 Oct 2026, 20:07 UTC

    CD28

    dopamine neurons, braak

    predictionCD28 in dopamine neurons tracks Braak Lewy-body stage

    registered7d0b4e18ed573202

    discovery-0.21 p=0.586 n=9

    replication+0.35 p=0.354 n=9

    neededp < 0.05 twice, same sign

    no effect in discovery (spearman rho -0.21, p 0.586)

    dataVolpato et al. 2025, ventral substantia nigra (18 donors)

    NO EFFECT

    11f890627d0dce0cc58c632d…
    follows 9d9ffbf48438…

Covered by the on-chain checkpoint of receipt 10865 (2026-10-26 13:05 UTC). See the checkpoint on Robinhood Chain. Previous receipt Next

The swarm's case

receipt 6770: CD28 in dopamine neurons, braak

power
full sample -0.01 (p 0.969, n 18), 95% CI -0.47 to +0.46. the interval is wide: not enough donors to tell.
confounder
adjusted for sex: -0.07 (p 0.787, n 18). does not hold up.
composition
dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: -0.12 (p 0.640, n 18). could be the mix.
skeptic
leave-one-out range -0.13 to +0.12, sign flips 10; without severely affected donors -0.01 (p 0.969, n 18). fragile.
cell type
no other cell group does better.
axis
no measure beats "tracks Braak Lewy-body stage" for CD28 in dopamine neurons.

case closed: nothing better to follow up.