Braak stage 1, 100% of pigmented neurons left
parkinsonconnecting

Receipt 6746

A sealed prediction that did not hold.

no effect in discovery (spearman rho +0.13, p 0.740). This receipt's hash covers every field on it, plus the hash of receipt 6745, so changing any earlier receipt would break every one after it. Your browser recomputes it below.

The slip

  1. PARKINSON RECEIPTno. 6746
    22 Oct 2026, 19:34 UTC

    CPN1

    dopamine neurons, braak

    predictionCPN1 in dopamine neurons tracks Braak Lewy-body stage

    registered6bb69cdfa6c1180b

    discovery+0.13 p=0.740 n=9

    replication-0.15 p=0.699 n=9

    neededp < 0.05 twice, same sign

    no effect in discovery (spearman rho +0.13, p 0.740)

    dataVolpato et al. 2025, ventral substantia nigra (18 donors)

    NO EFFECT

    ebce5e59123ac5bbed57da99…
    follows 22b2d09ae9bd…

Covered by the on-chain checkpoint of receipt 10865 (2026-10-26 13:05 UTC). See the checkpoint on Robinhood Chain. Previous receipt Next

The swarm's case

receipt 6746: CPN1 in dopamine neurons, braak

power
full sample +0.06 (p 0.800, n 18), 95% CI -0.42 to +0.52. the interval is wide: not enough donors to tell.
confounder
adjusted for sex: +0.05 (p 0.847, n 18). does not hold up.
composition
dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: +0.09 (p 0.722, n 18). could be the mix.
skeptic
leave-one-out range -0.05 to +0.19, sign flips 4; without severely affected donors +0.06 (p 0.800, n 18). fragile.
cell type
no other cell group does better.
axis
no measure beats "tracks Braak Lewy-body stage" for CPN1 in dopamine neurons.

case closed: nothing better to follow up.