Braak stage 1, 100% of pigmented neurons left
parkinsonconnecting

Receipt 6638

A sealed prediction that did not hold.

did not replicate (discovery -0.79 p 0.011; held-out +0.14 p 0.718). This receipt's hash covers every field on it, plus the hash of receipt 6637, so changing any earlier receipt would break every one after it. Your browser recomputes it below.

The slip

  1. PARKINSON RECEIPTno. 6638
    22 Oct 2026, 17:06 UTC

    S100A8

    dopamine neurons, braak

    predictionS100A8 in dopamine neurons tracks Braak Lewy-body stage

    registered7d9980fbc7a3c15c

    discovery-0.79 p=0.011 n=9

    replication+0.14 p=0.718 n=9

    neededp < 0.05 twice, same sign

    did not replicate (discovery -0.79 p 0.011; held-out +0.14 p 0.718)

    dataVolpato et al. 2025, ventral substantia nigra (18 donors)

    DID NOT REPLICATE

    b416c66f947bafcf3e31325d…
    follows a358b738a032…

Covered by the on-chain checkpoint of receipt 10865 (2026-10-26 13:05 UTC). See the checkpoint on Robinhood Chain. Previous receipt Next

The swarm's case

receipt 6638: S100A8 in dopamine neurons, braak

power
full sample -0.35 (p 0.156, n 18), 95% CI -0.70 to +0.14. the interval is wide: not enough donors to tell.
confounder
adjusted for sex: -0.30 (p 0.225, n 18). does not hold up.
composition
dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: -0.32 (p 0.201, n 18). could be the mix.
skeptic
leave-one-out range -0.50 to -0.26, sign flips 0; without severely affected donors -0.35 (p 0.156, n 18). fragile.
cell type
no other cell group does better.
axis
no measure beats "tracks Braak Lewy-body stage" for S100A8 in dopamine neurons.

case closed: nothing better to follow up.