Braak stage 1, 100% of pigmented neurons left
parkinsonconnecting

Receipt 6607

A sealed prediction that did not hold.

no effect in discovery (spearman rho -0.62, p 0.073). This receipt's hash covers every field on it, plus the hash of receipt 6606, so changing any earlier receipt would break every one after it. Your browser recomputes it below.

The slip

  1. PARKINSON RECEIPTno. 6607
    22 Oct 2026, 16:24 UTC

    PCNX2

    microglia, braak

    predictionPCNX2 in microglia tracks Braak Lewy-body stage

    registered8af466c5982991e4

    discovery-0.62 p=0.073 n=9

    replication-0.16 p=0.685 n=9

    neededp < 0.05 twice, same sign

    no effect in discovery (spearman rho -0.62, p 0.073)

    dataVolpato et al. 2025, ventral substantia nigra (18 donors)

    NO EFFECT

    e06f02fae94c02d74f87ea66…
    follows 9d972ad0af22…

Covered by the on-chain checkpoint of receipt 10865 (2026-10-26 13:05 UTC). See the checkpoint on Robinhood Chain. Previous receipt Next

The swarm's case

receipt 6607: PCNX2 in microglia, braak

power
full sample -0.39 (p 0.114, n 18), 95% CI -0.72 to +0.10. the interval is wide: not enough donors to tell.
confounder
adjusted for sex: -0.40 (p 0.103, n 18). does not hold up.
composition
microglia share of nuclei vs axis -0.11 (p 0.652); controlling for it: -0.40 (p 0.103, n 18). could be the mix.
skeptic
leave-one-out range -0.49 to -0.30, sign flips 0; without severely affected donors -0.39 (p 0.114, n 18). fragile.
cell type
no other cell group does better.
axis
no measure beats "tracks Braak Lewy-body stage" for PCNX2 in microglia.

case closed: nothing better to follow up.