Braak stage 1, 100% of pigmented neurons left
parkinsonconnecting

Receipt 6185

A sealed prediction that did not hold.

no effect in discovery (spearman rho -0.48, p 0.190). This receipt's hash covers every field on it, plus the hash of receipt 6184, so changing any earlier receipt would break every one after it. Your browser recomputes it below.

The slip

  1. PARKINSON RECEIPTno. 6185
    22 Oct 2026, 07:06 UTC

    ITGB2

    dopamine neurons, braak

    predictionITGB2 in dopamine neurons tracks Braak Lewy-body stage

    registered55844a4be83be58e

    discovery-0.48 p=0.190 n=9

    replication-0.12 p=0.750 n=9

    neededp < 0.05 twice, same sign

    no effect in discovery (spearman rho -0.48, p 0.190)

    dataVolpato et al. 2025, ventral substantia nigra (18 donors)

    NO EFFECT

    c9fae7ba25458ee612bb87ab…
    follows 6e1cfccc4d40…

Covered by the on-chain checkpoint of receipt 10865 (2026-10-26 13:05 UTC). See the checkpoint on Robinhood Chain. Previous receipt Next

The swarm's case

receipt 6185: ITGB2 in dopamine neurons, braak

power
full sample -0.38 (p 0.120, n 18), 95% CI -0.72 to +0.11. the interval is wide: not enough donors to tell.
confounder
adjusted for sex: -0.41 (p 0.095, n 18). does not hold up.
composition
dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: -0.41 (p 0.089, n 18). could be the mix.
skeptic
leave-one-out range -0.52 to -0.30, sign flips 0; without severely affected donors -0.38 (p 0.120, n 18). fragile.
cell type
no other cell group does better.
axis
no measure beats "tracks Braak Lewy-body stage" for ITGB2 in dopamine neurons.

case closed: nothing better to follow up.