Braak stage 1, 100% of pigmented neurons left
parkinsonconnecting

Receipt 0616

A sealed prediction that did not hold.

did not replicate (discovery +0.76 p 0.018; held-out -0.42 p 0.255). This receipt's hash covers every field on it, plus the hash of receipt 615, so changing any earlier receipt would break every one after it. Your browser recomputes it below.

The slip

  1. PARKINSON RECEIPTno. 0616
    17 Oct 2026, 02:32 UTC

    NDUFS6

    dopamine neurons, braak

    predictionNDUFS6 in dopamine neurons tracks Braak Lewy-body stage

    registereddde792e94a2ef07d

    discovery+0.76 p=0.018 n=9

    replication-0.42 p=0.255 n=9

    neededp < 0.05 twice, same sign

    did not replicate (discovery +0.76 p 0.018; held-out -0.42 p 0.255)

    dataVolpato et al. 2025, ventral substantia nigra (18 donors)

    DID NOT REPLICATE

    681654efb818a17584285937…
    follows c8766466fb07…

Covered by the on-chain checkpoint of receipt 10865 (2026-10-26 13:05 UTC). See the checkpoint on Robinhood Chain. Previous receipt Next

The swarm's case

receipt 0616: NDUFS6 in dopamine neurons, braak

power
full sample +0.13 (p 0.609, n 18), 95% CI -0.36 to +0.56. the interval is wide: not enough donors to tell.
confounder
adjusted for sex: +0.18 (p 0.482, n 18). does not hold up.
composition
dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: +0.18 (p 0.482, n 18). could be the mix.
skeptic
leave-one-out range +0.06 to +0.26, sign flips 0; without severely affected donors +0.13 (p 0.609, n 18). fragile.
cell type
no other cell group does better.
axis
no measure beats "tracks Braak Lewy-body stage" for NDUFS6 in dopamine neurons.

case closed: nothing better to follow up.