Braak stage 1, 100% of pigmented neurons left
parkinsonconnecting

Receipt 6146

A sealed prediction that did not hold.

no effect in discovery (spearman rho +0.24, p 0.539). This receipt's hash covers every field on it, plus the hash of receipt 6145, so changing any earlier receipt would break every one after it. Your browser recomputes it below.

The slip

  1. PARKINSON RECEIPTno. 6146
    22 Oct 2026, 06:13 UTC

    TRMT10A

    dopamine neurons, braak

    predictionTRMT10A in dopamine neurons tracks Braak Lewy-body stage

    registered6b43ddc3cde81778

    discovery+0.24 p=0.539 n=9

    replication+0.11 p=0.775 n=9

    neededp < 0.05 twice, same sign

    no effect in discovery (spearman rho +0.24, p 0.539)

    dataVolpato et al. 2025, ventral substantia nigra (18 donors)

    NO EFFECT

    a1087ecb53a44e4a77d78568…
    follows 76339d85500a…

Covered by the on-chain checkpoint of receipt 10865 (2026-10-26 13:05 UTC). See the checkpoint on Robinhood Chain. Previous receipt Next

The swarm's case

receipt 6146: TRMT10A in dopamine neurons, braak

power
full sample +0.17 (p 0.498, n 18), 95% CI -0.32 to +0.59. the interval is wide: not enough donors to tell.
confounder
adjusted for sex: +0.18 (p 0.476, n 18). does not hold up.
composition
dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: +0.19 (p 0.450, n 18). could be the mix.
skeptic
leave-one-out range +0.06 to +0.34, sign flips 0; without severely affected donors +0.17 (p 0.498, n 18). fragile.
cell type
no other cell group does better.
axis
no measure beats "tracks Braak Lewy-body stage" for TRMT10A in dopamine neurons.

case closed: nothing better to follow up.