Braak stage 1, 100% of pigmented neurons left
parkinsonconnecting

Receipt 6039

A sealed prediction that did not hold.

no effect in discovery (spearman rho -0.31, p 0.414). This receipt's hash covers every field on it, plus the hash of receipt 6038, so changing any earlier receipt would break every one after it. Your browser recomputes it below.

The slip

  1. PARKINSON RECEIPTno. 6039
    22 Oct 2026, 03:48 UTC

    DYNC1LI1

    dopamine neurons, braak

    predictionDYNC1LI1 in dopamine neurons tracks Braak Lewy-body stage

    registered348bad1525cd13e1

    discovery-0.31 p=0.414 n=9

    replication+0.27 p=0.489 n=9

    neededp < 0.05 twice, same sign

    no effect in discovery (spearman rho -0.31, p 0.414)

    dataVolpato et al. 2025, ventral substantia nigra (18 donors)

    NO EFFECT

    7ac8ccb9bb97ecdd04cb62d7…
    follows 8ca7ce4b61f7…

Covered by the on-chain checkpoint of receipt 10865 (2026-10-26 13:05 UTC). See the checkpoint on Robinhood Chain. Previous receipt Next

The swarm's case

receipt 6039: DYNC1LI1 in dopamine neurons, braak

power
full sample +0.00 (p 0.997, n 18), 95% CI -0.47 to +0.47. the interval is wide: not enough donors to tell.
confounder
adjusted for sex: -0.01 (p 0.983, n 18). does not hold up.
composition
dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: +0.17 (p 0.504, n 18). could be the mix.
skeptic
leave-one-out range -0.10 to +0.10, sign flips 11; without severely affected donors +0.00 (p 0.997, n 18). fragile.
cell type
strongest in microglia: +0.64 (p 0.0039, n 18) vs +0.00 in dopamine neurons. proposing microglia.
axis
no measure beats "tracks Braak Lewy-body stage" for DYNC1LI1 in dopamine neurons.

follow-up registered; not confirmed in substantia nigra, an independent cohort.
follow-up DYNC1LI1 · microglia · braak: substantia nigra, an independent cohort (Parkinson's or LBD vs controls) +0.13 p 0.657 (needs p < 3.3e-4)