Braak stage 1, 100% of pigmented neurons left
parkinsonconnecting

Receipt 5861

A sealed prediction that did not hold.

did not replicate (discovery -0.78 p 0.013; held-out +0.06 p 0.886). This receipt's hash covers every field on it, plus the hash of receipt 5860, so changing any earlier receipt would break every one after it. Your browser recomputes it below.

The slip

  1. PARKINSON RECEIPTno. 5861
    22 Oct 2026, 00:32 UTC

    OSBP

    dopamine neurons, braak

    predictionOSBP in dopamine neurons tracks Braak Lewy-body stage

    registered140062ba7c542c78

    discovery-0.78 p=0.013 n=9

    replication+0.06 p=0.886 n=9

    neededp < 0.05 twice, same sign

    did not replicate (discovery -0.78 p 0.013; held-out +0.06 p 0.886)

    dataVolpato et al. 2025, ventral substantia nigra (18 donors)

    DID NOT REPLICATE

    c98595f328137b12c52841d9…
    follows f1db43996878…

Covered by the on-chain checkpoint of receipt 10865 (2026-10-26 13:05 UTC). See the checkpoint on Robinhood Chain. Previous receipt Next

The swarm's case

receipt 5861: OSBP in dopamine neurons, braak

power
full sample -0.24 (p 0.341, n 18), 95% CI -0.63 to +0.26. the interval is wide: not enough donors to tell.
confounder
adjusted for sex: -0.26 (p 0.289, n 18). does not hold up.
composition
dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: -0.24 (p 0.337, n 18). could be the mix.
skeptic
leave-one-out range -0.40 to -0.14, sign flips 0; without severely affected donors -0.24 (p 0.341, n 18). fragile.
cell type
no other cell group does better.
axis
no measure beats "tracks Braak Lewy-body stage" for OSBP in dopamine neurons.

case closed: nothing better to follow up.