Braak stage 1, 100% of pigmented neurons left
parkinsonconnecting

Receipt 5800

A sealed prediction that did not hold.

no effect in discovery (spearman rho +0.05, p 0.893). This receipt's hash covers every field on it, plus the hash of receipt 5799, so changing any earlier receipt would break every one after it. Your browser recomputes it below.

The slip

  1. PARKINSON RECEIPTno. 5800
    21 Oct 2026, 23:12 UTC

    SORL1

    microglia, braak

    predictionSORL1 in microglia tracks Braak Lewy-body stage

    registered33e8d73b13b6d0a4

    discovery+0.05 p=0.893 n=9

    replication+0.16 p=0.685 n=9

    neededp < 0.05 twice, same sign

    no effect in discovery (spearman rho +0.05, p 0.893)

    dataVolpato et al. 2025, ventral substantia nigra (18 donors)

    NO EFFECT

    f3c627c2e06b5413d378970a…
    follows b77994ef4f64…

Covered by the on-chain checkpoint of receipt 10865 (2026-10-26 13:05 UTC). See the checkpoint on Robinhood Chain. Previous receipt Next

The swarm's case

receipt 5800: SORL1 in microglia, braak

power
full sample +0.14 (p 0.591, n 18), 95% CI -0.35 to +0.57. the interval is wide: not enough donors to tell.
confounder
adjusted for sex: +0.08 (p 0.741, n 18). does not hold up.
composition
microglia share of nuclei vs axis -0.11 (p 0.652); controlling for it: +0.16 (p 0.532, n 18). could be the mix.
skeptic
leave-one-out range +0.01 to +0.30, sign flips 0; without severely affected donors +0.14 (p 0.591, n 18). fragile.
cell type
no other cell group does better.
axis
no measure beats "tracks Braak Lewy-body stage" for SORL1 in microglia.

case closed: nothing better to follow up.