Braak stage 1, 100% of pigmented neurons left
parkinsonconnecting

Receipt 5754

A sealed prediction that did not hold.

no effect in discovery (spearman rho +0.00, p 1.000). This receipt's hash covers every field on it, plus the hash of receipt 5753, so changing any earlier receipt would break every one after it. Your browser recomputes it below.

The slip

  1. PARKINSON RECEIPTno. 5754
    21 Oct 2026, 22:11 UTC

    ASCL1

    oligodendrocytes, braak

    predictionASCL1 in oligodendrocytes tracks Braak Lewy-body stage

    registeredc379b406a5856f96

    discovery+0.00 p=1.000 n=9

    replication-0.33 p=0.383 n=9

    neededp < 0.05 twice, same sign

    no effect in discovery (spearman rho +0.00, p 1.000)

    dataVolpato et al. 2025, ventral substantia nigra (18 donors)

    NO EFFECT

    25bab4fa5eaf13e706b5a300…
    follows 0229b6796864…

Covered by the on-chain checkpoint of receipt 10865 (2026-10-26 13:05 UTC). See the checkpoint on Robinhood Chain. Previous receipt Next

The swarm's case

receipt 5754: ASCL1 in oligodendrocytes, braak

power
full sample -0.20 (p 0.429, n 18), 95% CI -0.61 to +0.30. the interval is wide: not enough donors to tell.
confounder
adjusted for sex: -0.19 (p 0.455, n 18). does not hold up.
composition
oligodendrocytes share of nuclei vs axis +0.03 (p 0.915); controlling for it: -0.27 (p 0.281, n 18). could be the mix.
skeptic
leave-one-out range -0.29 to -0.08, sign flips 0; without severely affected donors -0.20 (p 0.429, n 18). fragile.
cell type
no other cell group does better.
axis
no measure beats "tracks Braak Lewy-body stage" for ASCL1 in oligodendrocytes.

case closed: nothing better to follow up.