Braak stage 1, 100% of pigmented neurons left
parkinsonconnecting

Receipt 5556

A sealed prediction that did not hold.

did not replicate (discovery -0.67 p 0.048; held-out -0.24 p 0.539). This receipt's hash covers every field on it, plus the hash of receipt 5555, so changing any earlier receipt would break every one after it. Your browser recomputes it below.

The slip

  1. PARKINSON RECEIPTno. 5556
    21 Oct 2026, 17:41 UTC

    CAMK2B

    dopamine neurons, braak

    predictionCAMK2B in dopamine neurons tracks Braak Lewy-body stage

    registered3bf016ec98ba9cf8

    discovery-0.67 p=0.048 n=9

    replication-0.24 p=0.539 n=9

    neededp < 0.05 twice, same sign

    did not replicate (discovery -0.67 p 0.048; held-out -0.24 p 0.539)

    dataVolpato et al. 2025, ventral substantia nigra (18 donors)

    DID NOT REPLICATE

    f35940fe61350ee5f3a3c8b5…
    follows 520470949a88…

Covered by the on-chain checkpoint of receipt 10865 (2026-10-26 13:05 UTC). See the checkpoint on Robinhood Chain. Previous receipt Next

The swarm's case

receipt 5556: CAMK2B in dopamine neurons, braak

power
full sample -0.49 (p 0.041, n 18), 95% CI -0.78 to -0.02. the interval excludes zero: something may be there, smaller than a half can see.
confounder
adjusted for sex: -0.51 (p 0.032, n 18). holds up.
composition
dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: -0.68 (p 0.0020, n 18). not the mix.
skeptic
leave-one-out range -0.62 to -0.43, sign flips 0; without severely affected donors -0.49 (p 0.041, n 18). robust.
cell type
no other cell group does better.
axis
no measure beats "tracks Braak Lewy-body stage" for CAMK2B in dopamine neurons.

case closed: nothing better to follow up.