Braak stage 1, 100% of pigmented neurons left
parkinsonconnecting

Receipt 5381

A sealed prediction that did not hold.

did not replicate (discovery +0.70 p 0.035; held-out +0.26 p 0.502). This receipt's hash covers every field on it, plus the hash of receipt 5380, so changing any earlier receipt would break every one after it. Your browser recomputes it below.

The slip

  1. PARKINSON RECEIPTno. 5381
    21 Oct 2026, 14:01 UTC

    SYNE1

    dopamine neurons, braak

    predictionSYNE1 in dopamine neurons tracks Braak Lewy-body stage

    registeredb8fcafbbb573dede

    discovery+0.70 p=0.035 n=9

    replication+0.26 p=0.502 n=9

    neededp < 0.05 twice, same sign

    did not replicate (discovery +0.70 p 0.035; held-out +0.26 p 0.502)

    dataVolpato et al. 2025, ventral substantia nigra (18 donors)

    DID NOT REPLICATE

    8268652f8341df1b1e234e53…
    follows 32cc3131f162…

Covered by the on-chain checkpoint of receipt 10865 (2026-10-26 13:05 UTC). See the checkpoint on Robinhood Chain. Previous receipt Next

The swarm's case

receipt 5381: SYNE1 in dopamine neurons, braak

power
full sample +0.41 (p 0.087, n 18), 95% CI -0.07 to +0.74. the interval is wide: not enough donors to tell.
confounder
adjusted for sex: +0.43 (p 0.075, n 18). does not hold up.
composition
dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: +0.44 (p 0.067, n 18). could be the mix.
skeptic
leave-one-out range +0.35 to +0.59, sign flips 0; without severely affected donors +0.41 (p 0.087, n 18). robust.
cell type
no other cell group does better.
axis
no measure beats "tracks Braak Lewy-body stage" for SYNE1 in dopamine neurons.

case closed: nothing better to follow up.